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APP-BP1 mediates APP-induced apoptosis and DNA synthesis and is increased in Alzheimer's disease brain
APP-BP1, first identified as an amyloid precursor protein (APP) binding protein, is the regulatory subunit of the activating enzyme for the small ubiquitin-like protein NEDD8. We have shown that APP-BP1 drives the S- to M-phase transition in dividing cells, and causes apoptosis in neurons (Chen, Y.,...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
The Rockefeller University Press
2003
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2173435/ https://ncbi.nlm.nih.gov/pubmed/14557245 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200304003 |
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