IκB Kinase β Phosphorylates the K63 Deubiquitinase A20 To Cause Feedback Inhibition of the NF-κB Pathway

Misregulation of NF-κB signaling leads to infectious, inflammatory, or autoimmune disorders. IκB kinase β (IKKβ) is an essential activator of NF-κB and is known to phosphorylate the NF-κB inhibitor, IκBα, allowing it to undergo ubiquitin-mediated proteasomal degradation. However, beyond IκBα, few ad...

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Bibliografiske detaljer
Main Authors: Hutti, Jessica E., Turk, Benjamin E., Asara, John M., Ma, Averil, Cantley, Lewis C., Abbott, Derek W.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2007
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2169042/
https://ncbi.nlm.nih.gov/pubmed/17709380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01101-07
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