IκB Kinase α Phosphorylation of TRAF4 Downregulates Innate Immune Signaling

Despite their homology, IκB kinase α (IKKα) and IKKβ have divergent roles in NF-κB signaling. IKKβ strongly activates NF-κB while IKKα can downregulate NF-κB under certain circumstances. Given this, identifying independent substrates for these kinases could help delineate their divergent roles. Pept...

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Main Authors: Marinis, Jill M., Hutti, Jessica E., Homer, Craig R., Cobb, Brian A., Cantley, Lewis C., McDonald, Christine, Abbott, Derek W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3434482/
https://ncbi.nlm.nih.gov/pubmed/22547678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00106-12
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