TRAF6-Dependent Act1 Phosphorylation by the IκB Kinase-Related Kinases Suppresses Interleukin-17-Induced NF-κB Activation

Interleukin-17 (IL-17) is critically involved in the pathogenesis of various inflammatory disorders. IL-17 receptor (IL-17R)-proximal signaling complex (IL-17R-Act1-TRAF6) is essential for IL-17-mediated NF-κB activation, while IL-17-mediated mRNA stability is TRAF6 independent. Recently, inducible...

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Main Authors: Qu, Fangfang, Gao, Hanchao, Zhu, Shu, Shi, Peiqing, Zhang, Yifan, Liu, Yan, Jallal, Bahija, Yao, Yihong, Shi, Yufang, Qian, Youcun
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3457531/
https://ncbi.nlm.nih.gov/pubmed/22851696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00268-12
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