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The deubiquitinase activity of A20 is dispensable for NF-κB signaling
A20 has been suggested to limit NF-κB activation by removing regulatory ubiquitin chains from ubiquitinated substrates. A20 is a ubiquitin-editing enzyme that removes K63-linked ubiquitin chains from adaptor proteins, such as RIP1, and then conjugates them to K48-linked polyubiquitin chains to trigg...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BlackWell Publishing Ltd
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4196981/ https://ncbi.nlm.nih.gov/pubmed/24878851 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201338305 |
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