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Severe Acute Respiratory Syndrome Coronavirus Evades Antiviral Signaling: Role of nsp1 and Rational Design of an Attenuated Strain

The severe acute respiratory syndrome (SARS) epidemic was caused by the spread of a previously unrecognized infectious agent, the SARS-associated coronavirus (SARS-CoV). Here we show that SARS-CoV could inhibit both virus- and interferon (IFN)-dependent signaling, two key steps of the antiviral resp...

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Bibliografski detalji
Glavni autori: Wathelet, Marc G., Orr, Melissa, Frieman, Matthew B., Baric, Ralph S.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 2007
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2168762/
https://ncbi.nlm.nih.gov/pubmed/17715225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00702-07
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