The nsp1, nsp13, and M Proteins Contribute to the Hepatotropism of Murine Coronavirus JHM.WU

Mouse hepatitis virus (MHV) isolates JHM.WU and JHM.SD promote severe central nervous system disease. However, while JHM.WU replicates robustly and induces hepatitis, JHM.SD fails to replicate or induce pathology in the liver. These two JHM variants encode homologous proteins with few polymorphisms,...

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Udgivet i:J Virol
Main Authors: Zhang, Rong, Li, Yize, Cowley, Timothy J., Steinbrenner, Adam D., Phillips, Judith M., Yount, Boyd L., Baric, Ralph S., Weiss, Susan R.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2015
Fag:
Pathogenesis and Immunity
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4403414/
https://ncbi.nlm.nih.gov/pubmed/25589656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03535-14
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