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The nsp1, nsp13, and M Proteins Contribute to the Hepatotropism of Murine Coronavirus JHM.WU

Mouse hepatitis virus (MHV) isolates JHM.WU and JHM.SD promote severe central nervous system disease. However, while JHM.WU replicates robustly and induces hepatitis, JHM.SD fails to replicate or induce pathology in the liver. These two JHM variants encode homologous proteins with few polymorphisms,...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Zhang, Rong, Li, Yize, Cowley, Timothy J., Steinbrenner, Adam D., Phillips, Judith M., Yount, Boyd L., Baric, Ralph S., Weiss, Susan R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4403414/
https://ncbi.nlm.nih.gov/pubmed/25589656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03535-14
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