The nsp3 Macrodomain Promotes Virulence in Mice with Coronavirus-Induced Encephalitis

All coronaviruses encode a macrodomain containing ADP-ribose-1″-phosphatase (ADRP) activity within the N terminus of nonstructural protein 3 (nsp3). Previous work showed that mouse hepatitis virus strain A59 (MHV-A59) with a mutated catalytic site (N1348A) replicated similarly to wild-type virus but...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Virol
Prif Awduron: Fehr, Anthony R., Athmer, Jeremiah, Channappanavar, Rudragouda, Phillips, Judith M., Meyerholz, David K., Perlman, Stanley
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology 2014
Pynciau:
Pathogenesis and Immunity
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4300739/
https://ncbi.nlm.nih.gov/pubmed/25428866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02596-14
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