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The nsp3 Macrodomain Promotes Virulence in Mice with Coronavirus-Induced Encephalitis
All coronaviruses encode a macrodomain containing ADP-ribose-1″-phosphatase (ADRP) activity within the N terminus of nonstructural protein 3 (nsp3). Previous work showed that mouse hepatitis virus strain A59 (MHV-A59) with a mutated catalytic site (N1348A) replicated similarly to wild-type virus but...
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| Publicado no: | J Virol |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4300739/ https://ncbi.nlm.nih.gov/pubmed/25428866 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02596-14 |
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