The Conserved Coronavirus Macrodomain Promotes Virulence and Suppresses the Innate Immune Response during Severe Acute Respiratory Syndrome Coronavirus Infection

ADP-ribosylation is a common posttranslational modification that may have antiviral properties and impact innate immunity. To regulate this activity, macrodomain proteins enzymatically remove covalently attached ADP-ribose from protein targets. All members of the Coronavirinae, a subfamily of positi...

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Detalhes bibliográficos
Publicado no:mBio
Main Authors: Fehr, Anthony R., Channappanavar, Rudragouda, Jankevicius, Gytis, Fett, Craig, Zhao, Jincun, Athmer, Jeremiah, Meyerholz, David K., Ahel, Ivan, Perlman, Stanley
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5156301/
https://ncbi.nlm.nih.gov/pubmed/27965448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.01721-16
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