Selective Packaging in Murine Coronavirus Promotes Virulence by Limiting Type I Interferon Responses

Selective packaging is a mechanism used by multiple virus families to specifically incorporate genomic RNA (gRNA) into virions and exclude other types of RNA. Lineage A betacoronaviruses incorporate a 95-bp stem-loop structure, the packaging signal (PS), into the nsp15 locus of ORF1b that is both ne...

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Pubblicato in:mBio
Autori principali: Athmer, Jeremiah, Fehr, Anthony R., Grunewald, Matthew E., Qu, Wen, Wheeler, D. Lori, Graepel, Kevin W., Channappanavar, Rudragouda, Sekine, Aimee, Aldabeeb, Dana Saud, Gale, Michael, Denison, Mark R., Perlman, Stanley
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2018
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5930304/
https://ncbi.nlm.nih.gov/pubmed/29717007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00272-18
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