Attenuation and Restoration of Severe Acute Respiratory Syndrome Coronavirus Mutant Lacking 2′-O-Methyltransferase Activity

The sudden emergence of severe acute respiratory syndrome coronavirus (SARS-CoV) in 2002 and, more recently, Middle Eastern respiratory syndrome CoV (MERS-CoV) underscores the importance of understanding critical aspects of CoV infection and pathogenesis. Despite significant insights into CoV cross-...

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Bibliographic Details
Main Authors: Menachery, Vineet D., Yount, Boyd L., Josset, Laurence, Gralinski, Lisa E., Scobey, Trevor, Agnihothram, Sudhakar, Katze, Michael G., Baric, Ralph S.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2014
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3993736/
https://ncbi.nlm.nih.gov/pubmed/24478444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03571-13
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