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Characterization of covalent Adriamycin-DNA adducts

Adriamycin is a popular antineoplastic agent whose ability to form covalent adducts with DNA has been correlated to cellular apoptosis (programmed cell death) in tumor models. We have isolated and purified this adduct formed under oxido-reductive (Fenton) conditions in Tris buffer. We show by homo-...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Zeman, Steven M., Phillips, Don R., Crothers, Donald M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 1998
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC21680/
https://ncbi.nlm.nih.gov/pubmed/9751705
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