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Characterization of covalent Adriamycin-DNA adducts

Adriamycin is a popular antineoplastic agent whose ability to form covalent adducts with DNA has been correlated to cellular apoptosis (programmed cell death) in tumor models. We have isolated and purified this adduct formed under oxido-reductive (Fenton) conditions in Tris buffer. We show by homo-...

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Bibliografski detalji
Glavni autori: Zeman, Steven M., Phillips, Don R., Crothers, Donald M.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 1998
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC21680/
https://ncbi.nlm.nih.gov/pubmed/9751705
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