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Drug concentration heterogeneity facilitates the evolution of drug resistance

Pathogenic microorganisms use Darwinian processes to circumvent attempts at their control through chemotherapy. In the case of HIV-1 infection, in which drug resistance is a continuing problem, we show that in one-compartment systems, there is a relatively narrow window of drug concentrations that a...

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Hlavní autoři: Kepler, Thomas B., Perelson, Alan S.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 1998
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC21672/
https://ncbi.nlm.nih.gov/pubmed/9751697
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