Spatial Heterogeneity in Drug Concentrations Can Facilitate the Emergence of Resistance to Cancer Therapy

Acquired resistance is one of the major barriers to successful cancer therapy. The development of resistance is commonly attributed to genetic heterogeneity. However, heterogeneity of drug penetration of the tumor microenvironment both on the microscopic level within solid tumors as well as on the m...

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Bibliographic Details
Published in:PLoS Comput Biol
Main Authors: Fu, Feng, Nowak, Martin A., Bonhoeffer, Sebastian
Format: Artigo
Language:Inglês
Published: Public Library of Science 2015
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4366398/
https://ncbi.nlm.nih.gov/pubmed/25789469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1004142
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