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Timing and heterogeneity of mutations associated with drug resistance in metastatic cancers
Targeted therapies provide an exciting new approach to combat human cancer. The immediate effect is a dramatic reduction in disease burden, but in most cases, the tumor returns as a consequence of resistance. Various mechanisms for the evolution of resistance have been implicated, including mutation...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2014
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4234551/ https://ncbi.nlm.nih.gov/pubmed/25349424 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1412075111 |
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