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Timing and heterogeneity of mutations associated with drug resistance in metastatic cancers
Targeted therapies provide an exciting new approach to combat human cancer. The immediate effect is a dramatic reduction in disease burden, but in most cases, the tumor returns as a consequence of resistance. Various mechanisms for the evolution of resistance have been implicated, including mutation...
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| 出版年: | Proc Natl Acad Sci U S A |
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| 主要な著者: | , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2014
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4234551/ https://ncbi.nlm.nih.gov/pubmed/25349424 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1412075111 |
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