Drug concentration heterogeneity facilitates the evolution of drug resistance
Pathogenic microorganisms use Darwinian processes to circumvent attempts at their control through chemotherapy. In the case of HIV-1 infection, in which drug resistance is a continuing problem, we show that in one-compartment systems, there is a relatively narrow window of drug concentrations that a...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1998
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC21672/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9751697/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.20.11514 |
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