The Impact of Microenvironmental Heterogeneity on the Evolution of Drug Resistance in Cancer Cells

Therapeutic resistance arises as a result of evolutionary processes driven by dynamic feedback between a heterogeneous cell population and environmental selective pressures. Previous studies have suggested that mutations conferring resistance to epidermal growth factor receptor (EGFR) tyrosine kinas...

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Bibliografiska uppgifter
I publikationen:Cancer Inform
Huvudupphovsmän: Mumenthaler, Shannon M, Foo, Jasmine, Choi, Nathan C, Heise, Nicholas, Leder, Kevin, Agus, David B, Pao, William, Michor, Franziska, Mallick, Parag
Materialtyp: Artigo
Språk:Inglês
Publicerad: Libertas Academica 2015
Ämnen:
Original Research
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4504404/
https://ncbi.nlm.nih.gov/pubmed/26244007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4137/CIN.S19338
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