Kinetic theory of fibrillogenesis of amyloid β-protein

Prior quasielastic light scattering (QLS) studies of fibrillogenesis of synthetic amyloid β-protein (Aβ)-(1–40) at low pH have suggested a kinetic model in which: (i) fibrillogenesis requires a nucleation step; (ii) nuclei are produced by Aβ micelles in addition to seeds initially present; and (iii)...

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Autores principales: Lomakin, Aleksey, Teplow, David B., Kirschner, Daniel A., Benedek, George B.
Formato: Artigo
Lenguaje:Inglês
Publicado: The National Academy of Sciences of the USA 1997
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC21534/
https://ncbi.nlm.nih.gov/pubmed/9223292
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