On the nucleation and growth of amyloid beta-protein fibrils: detection of nuclei and quantitation of rate constants.
We have studied the fibrillogenesis of synthetic amyloid beta-protein-(1-40) fragment (A beta) in 0.1 M HCl. At low pH, A beta formed fibrils at a rate amenable to detailed monitoring by quasi-elastic light-scattering spectroscopy. Examination of the fibrils with circular dichroism spectroscopy and...
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| Yayımlandı: | Proc Natl Acad Sci U S A |
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| Asıl Yazarlar: | , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
National Academy of Sciences
1996
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC40042/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8577726/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.3.1125 |
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