Crystal cataracts: Human genetic cataract caused by protein crystallization

Several human genetic cataracts have been linked recently to point mutations in the γD crystallin gene. Here we provide a molecular basis for lens opacity in two genetic cataracts and suggest that the opacity occurs because of the spontaneous crystallization of the mutant proteins. Such crystallizat...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Pande, Ajay, Pande, Jayanti, Asherie, Neer, Lomakin, Aleksey, Ogun, Olutayo, King, Jonathan, Benedek, George B.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2001
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC33431/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11371638/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.101124798
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