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Kinetic theory of fibrillogenesis of amyloid β-protein

Prior quasielastic light scattering (QLS) studies of fibrillogenesis of synthetic amyloid β-protein (Aβ)-(1–40) at low pH have suggested a kinetic model in which: (i) fibrillogenesis requires a nucleation step; (ii) nuclei are produced by Aβ micelles in addition to seeds initially present; and (iii)...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Lomakin, Aleksey, Teplow, David B., Kirschner, Daniel A., Benedek, George B.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1997
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC21534/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9223292/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.15.7942
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