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Structure determination of micelle-like intermediates in amyloid β-protein fibril assembly by using small angle neutron scattering

Increasing evidence supports the hypothesis that amyloid β-protein (Aβ) assembly is a key pathogenic feature of Alzheimer's disease. Thus, understanding the assembly process offers opportunities for the development of strategies for treating this devastating disease. In prior studies, Aβ was fo...

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Autors principals: Yong, Winnie, Lomakin, Aleksey, Kirkitadze, Marina D., Teplow, David B., Chen, Sow-Hsin, Benedek, George B.
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences 2002
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC117530/
https://ncbi.nlm.nih.gov/pubmed/11756677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.012584899
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