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Structure determination of micelle-like intermediates in amyloid β-protein fibril assembly by using small angle neutron scattering

Increasing evidence supports the hypothesis that amyloid β-protein (Aβ) assembly is a key pathogenic feature of Alzheimer's disease. Thus, understanding the assembly process offers opportunities for the development of strategies for treating this devastating disease. In prior studies, Aβ was fo...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Yong, Winnie, Lomakin, Aleksey, Kirkitadze, Marina D., Teplow, David B., Chen, Sow-Hsin, Benedek, George B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The National Academy of Sciences 2002
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC117530/
https://ncbi.nlm.nih.gov/pubmed/11756677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.012584899
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