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Role of Charged Residues in the S1–S4 Voltage Sensor of BK Channels

The activation of large conductance Ca(2+)-activated (BK) potassium channels is weakly voltage dependent compared to Shaker and other voltage-gated K(+) (K(V)) channels. Yet BK and K(V) channels share many conserved charged residues in transmembrane segments S1–S4. We mutated these residues individu...

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Detalhes bibliográficos
Main Authors: Ma, Zhongming, Lou, Xing Jian, Horrigan, Frank T.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2151507/
https://ncbi.nlm.nih.gov/pubmed/16505150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.200509421
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