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An Extracellular Cu(2+) Binding Site in the Voltage Sensor of BK and Shaker Potassium Channels

Copper is an essential trace element that may serve as a signaling molecule in the nervous system. Here we show that extracellular Cu(2+) is a potent inhibitor of BK and Shaker K(+) channels. At low micromolar concentrations, Cu(2+) rapidly and reversibly reduces macrosocopic K(+) conductance (G(K))...

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Bibliografische gegevens
Hoofdauteurs: Ma, Zhongming, Wong, Kin Yu, Horrigan, Frank T.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The Rockefeller University Press 2008
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2346571/
https://ncbi.nlm.nih.gov/pubmed/18443360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.200809980
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