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Localizing frustration in native proteins and protein assemblies

We propose a method of quantifying the degree of frustration manifested by spatially local interactions in protein biomolecules. This method of localization smoothly generalizes the global criterion for an energy landscape to be funneled to the native state, which is in keeping with the principle of...

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Autors principals: Ferreiro, Diego U., Hegler, Joseph A., Komives, Elizabeth A., Wolynes, Peter G.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2007
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2148382/
https://ncbi.nlm.nih.gov/pubmed/18077414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0709915104
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