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On the role of frustration in the energy landscapes of allosteric proteins
Natural protein domains must be sufficiently stable to fold but often need to be locally unstable to function. Overall, strong energetic conflicts are minimized in native states satisfying the principle of minimal frustration. Local violations of this principle open up possibilities to form the comp...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3048099/ https://ncbi.nlm.nih.gov/pubmed/21273505 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1018980108 |
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