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Localizing frustration in native proteins and protein assemblies

We propose a method of quantifying the degree of frustration manifested by spatially local interactions in protein biomolecules. This method of localization smoothly generalizes the global criterion for an energy landscape to be funneled to the native state, which is in keeping with the principle of...

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Detalhes bibliográficos
Main Authors: Ferreiro, Diego U., Hegler, Joseph A., Komives, Elizabeth A., Wolynes, Peter G.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2148382/
https://ncbi.nlm.nih.gov/pubmed/18077414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0709915104
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