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Consequences of localized frustration for the folding mechanism of the IM7 protein
In the laboratory, IM7 has been found to have an unusual folding mechanism in which an “on-pathway” intermediate with nonnative interactions is formed. We show that this intermediate is a consequence of an unusual cluster of highly frustrated interactions in the native structure. This cluster is inv...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2007
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2148258/ https://ncbi.nlm.nih.gov/pubmed/18077415 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0709922104 |
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