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Consequences of localized frustration for the folding mechanism of the IM7 protein

In the laboratory, IM7 has been found to have an unusual folding mechanism in which an “on-pathway” intermediate with nonnative interactions is formed. We show that this intermediate is a consequence of an unusual cluster of highly frustrated interactions in the native structure. This cluster is inv...

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Hlavní autoři: Sutto, Ludovico, Lätzer, Joachim, Hegler, Joseph A., Ferreiro, Diego U., Wolynes, Peter G.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2007
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2148258/
https://ncbi.nlm.nih.gov/pubmed/18077415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0709922104
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