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Fuzziness and Frustration in the Energy Landscape of Protein Folding, Function, and Assembly

[Image: see text] Are all protein interactions fully optimized? Do suboptimal interactions compromise specificity? What is the functional impact of frustration? Why does evolution not optimize some contacts? Proteins and their complexes are best described as ensembles of states populating an energy...

詳細記述

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書誌詳細
出版年:Acc Chem Res
主要な著者: Gianni, Stefano, Freiberger, María Inés, Jemth, Per, Ferreiro, Diego U., Wolynes, Peter G., Fuxreiter, Monika
フォーマット: Artigo
言語:Inglês
出版事項: American Chemical Society 2021
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC8023570/
https://ncbi.nlm.nih.gov/pubmed/33550810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.accounts.0c00813
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