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Fuzziness and Frustration in the Energy Landscape of Protein Folding, Function, and Assembly
[Image: see text] Are all protein interactions fully optimized? Do suboptimal interactions compromise specificity? What is the functional impact of frustration? Why does evolution not optimize some contacts? Proteins and their complexes are best described as ensembles of states populating an energy...
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| Опубликовано в: : | Acc Chem Res |
|---|---|
| Главные авторы: | , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Chemical
Society
2021
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| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8023570/ https://ncbi.nlm.nih.gov/pubmed/33550810 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.accounts.0c00813 |
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