Fuzziness and Frustration in the Energy Landscape of Protein Folding, Function, and Assembly

[Image: see text] Are all protein interactions fully optimized? Do suboptimal interactions compromise specificity? What is the functional impact of frustration? Why does evolution not optimize some contacts? Proteins and their complexes are best described as ensembles of states populating an energy...

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Bibliographic Details
Published in:Acc Chem Res
Main Authors: Gianni, Stefano, Freiberger, María Inés, Jemth, Per, Ferreiro, Diego U., Wolynes, Peter G., Fuxreiter, Monika
Format: Artigo
Language:Inglês
Published: American Chemical Society 2021
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8023570/
https://ncbi.nlm.nih.gov/pubmed/33550810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.accounts.0c00813
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