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Fuzziness and Frustration in the Energy Landscape of Protein Folding, Function, and Assembly
[Image: see text] Are all protein interactions fully optimized? Do suboptimal interactions compromise specificity? What is the functional impact of frustration? Why does evolution not optimize some contacts? Proteins and their complexes are best described as ensembles of states populating an energy...
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| 發表在: | Acc Chem Res |
|---|---|
| Main Authors: | , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Chemical
Society
2021
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| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8023570/ https://ncbi.nlm.nih.gov/pubmed/33550810 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.accounts.0c00813 |
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