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Fuzziness and Frustration in the Energy Landscape of Protein Folding, Function, and Assembly

[Image: see text] Are all protein interactions fully optimized? Do suboptimal interactions compromise specificity? What is the functional impact of frustration? Why does evolution not optimize some contacts? Proteins and their complexes are best described as ensembles of states populating an energy...

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Dettagli Bibliografici
Pubblicato in:Acc Chem Res
Autori principali: Gianni, Stefano, Freiberger, María Inés, Jemth, Per, Ferreiro, Diego U., Wolynes, Peter G., Fuxreiter, Monika
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2021
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8023570/
https://ncbi.nlm.nih.gov/pubmed/33550810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.accounts.0c00813
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