Essential role of Epac2/Rap1 signaling in regulation of insulin granule dynamics by cAMP

cAMP is well known to regulate exocytosis in various secretory cells, but the precise mechanism of its action remains unknown. Here, we examine the role of cAMP signaling in the exocytotic process of insulin granules in pancreatic beta cells. Although activation of cAMP signaling alone does not caus...

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Detalhes bibliográficos
Main Authors: Shibasaki, Tadao, Takahashi, Harumi, Miki, Takashi, Sunaga, Yasuhiro, Matsumura, Kimio, Yamanaka, Mami, Zhang, Changliang, Tamamoto, Atsuko, Satoh, Takaya, Miyazaki, Jun-ichi, Seino, Susumu
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2148290/
https://ncbi.nlm.nih.gov/pubmed/18040047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0707054104
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