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Epidermal growth factor receptor juxtamembrane region regulates allosteric tyrosine kinase activation

Structural studies of the extracellular and tyrosine kinase domains of the epidermal growth factor receptor (ErbB-1) provide considerable insight into facets of the receptor activation mechanism, but the contributions of other regions of ErbB-1 have not been ascertained. This study demonstrates that...

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Hlavní autoři: Thiel, Kristina W., Carpenter, Graham
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2007
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2148274/
https://ncbi.nlm.nih.gov/pubmed/18042729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0703854104
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