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Reduced receptor editing in lupus-prone MRL/lpr mice
The initial B cell repertoire contains a considerable proportion of autoreactive specificities. The first major B cell tolerance checkpoint is at the stage of the immature B cell, where receptor editing is the primary mode of eliminating self-reactivity. The cells that emigrate from the bone marrow...
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| Main Authors: | , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
The Rockefeller University Press
2007
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2118512/ https://ncbi.nlm.nih.gov/pubmed/17967905 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20071268 |
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