Targeting mitochondrial oxidative stress with MitoQ reduces NET formation and kidney disease in lupus-prone MRL-lpr mice

OBJECTIVES: Recent investigations in humans and mouse models with lupus have revealed evidence of mitochondrial dysfunction and production of mitochondrial reactive oxygen species (mROS) in T cells and neutrophils. This can provoke numerous cellular changes including oxidation of nucleic acids, prot...

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Bibliographische Detailangaben
Veröffentlicht in:Lupus Sci Med
Hauptverfasser: Fortner, Karen A, Blanco, Luz P, Buskiewicz, Iwona, Huang, Nick, Gibson, Pamela C, Cook, Deborah L, Pedersen, Hege L, Yuen, Peter S T, Murphy, Michael P, Perl, Andras, Kaplan, Mariana J, Budd, Ralph C
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMJ Publishing Group 2020
Schlagworte:
Animal Models
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7199895/
https://ncbi.nlm.nih.gov/pubmed/32343673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/lupus-2020-000387
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