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Somatic hypermutation: activation-induced deaminase for C/G followed by polymerase η for A/T
Somatic hypermutation (SHM) introduces nucleotide substitutions into immunoglobulin variable (Ig V) region genes at all four bases, but the mutations at C/G and A/T pairs are achieved by distinct mechanisms. Mutations at C/G pairs are a direct consequence of the C→U deamination catalyzed by activati...
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| 主要な著者: | , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
The Rockefeller University Press
2007
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2118430/ https://ncbi.nlm.nih.gov/pubmed/17190841 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20062409 |
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