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Mechanism of somatic hypermutation at the WA motif by human DNA polymerase η
Somatic hypermutation is programmed base substitutions in the variable regions of Ig genes for high-affinity antibody generation. Two motifs, RGYW and WA (R, purine; Y, pyrimidine; W, A or T), have been found to be somatic hypermutation hotspots. Overwhelming evidence suggests that DNA polymerase η...
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| Main Authors: | , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
National Academy of Sciences
2013
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3657764/ https://ncbi.nlm.nih.gov/pubmed/23630267 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1303126110 |
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