Structure and Mechanism of Human DNA Polymerase η

The variant form of human xeroderma pigmentosum syndrome (XPV) is caused by a deficiency in DNA polymerase η (Pol η) that enables replication through sunlight-induced pyrimidine dimers. We report high-resolution crystal structures of human Pol η at four consecutive steps during DNA synthesis through...

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Autori principali: Biertümpfel, Christian, Zhao, Ye, Kondo, Yuji, Ramón-Maiques, Santiago, Gregory, Mark, Lee, Jae Young, Masutani, Chikahide, Lehmann, Alan R., Hanaoka, Fumio, Yang, Wei
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2899710/
https://ncbi.nlm.nih.gov/pubmed/20577208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature09196
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