Correlation of somatic hypermutation specificity and A-T base pair substitution errors by DNA polymerase η during copying of a mouse immunoglobulin κ light chain transgene

To test the hypothesis that inaccurate DNA synthesis by mammalian DNA polymerase η (pol η) contributes to somatic hypermutation (SHM) of Ig genes, we measured the error specificity of mouse pol η during synthesis of each strand of a mouse Ig κ light chain transgene. We then compared the results to t...

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Main Authors: Pavlov, Youri I., Rogozin, Igor B., Galkin, Alexey P., Aksenova, Anna Y., Hanaoka, Fumio, Rada, Christina, Kunkel, Thomas A.
Formato: Artigo
Idioma:Inglês
Publicado: The National Academy of Sciences 2002
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC126606/
https://ncbi.nlm.nih.gov/pubmed/12119399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.152126799
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