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Somatic hypermutation of an immunoglobulin mu heavy chain transgene

We have analyzed somatic hypermutation of an immunoglobulin (Ig) heavy chain transgene. Hybridomas expressing the transgene were produced from immunized transgenic mice and transgene copies were sequenced to assay for mutation. In two IgM-producing hybridomas, as well as in several IgG-producing hyb...

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Detalhes bibliográficos
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 1993
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2190889/
https://ncbi.nlm.nih.gov/pubmed/8426117
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