The polymerase complex genes contribute to the high virulence of the human H5N1 influenza virus isolate A/Vietnam/1203/04

H5N1 influenza viruses transmitted from poultry to humans in Asia cause high mortality and pose a pandemic threat. Viral genes important for cell tropism and replication efficiency must be identified to elucidate and target virulence factors. We applied reverse genetics to generate H5N1 reassortants...

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Main Authors: Salomon, Rachelle, Franks, John, Govorkova, Elena A., Ilyushina, Natalia A., Yen, Hui-Ling, Hulse-Post, Diane J., Humberd, Jennifer, Trichet, Michel, Rehg, Jerold E., Webby, Richard J., Webster, Robert G., Hoffmann, Erich
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2006
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2118237/
https://ncbi.nlm.nih.gov/pubmed/16533883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20051938
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