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Neuraminidase Inhibitor-Resistant Recombinant A/Vietnam/1203/04 (H5N1) Influenza Viruses Retain Their Replication Efficiency and Pathogenicity In Vitro and In Vivo

Effective antiviral drugs are essential for early control of an influenza pandemic. It is therefore crucial to evaluate the possible threat posed by neuraminidase (NA) inhibitor-resistant influenza viruses with pandemic potential. Four NA mutations (E119G, H274Y, R292K, and N294S) that have been rep...

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Detalhes bibliográficos
Main Authors: Yen, Hui-Ling, Ilyushina, Natalia A., Salomon, Rachelle, Hoffmann, Erich, Webster, Robert G., Govorkova, Elena A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2169015/
https://ncbi.nlm.nih.gov/pubmed/17855542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01067-07
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