Neuraminidase Inhibitor-Resistant Influenza Viruses May Differ Substantially in Fitness and Transmissibility

Mutations of the conserved residues of influenza virus neuraminidase (NA) that are associated with NA inhibitor (NAI) resistance decrease the sialidase activity and/or stability of the NA, thus compromising viral fitness. In fact, clinically derived NAI-resistant variants with different NA mutations...

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Main Authors: Yen, Hui-Ling, Herlocher, Louise M., Hoffmann, Erich, Matrosovich, Mikhail N., Monto, Arnold S., Webster, Robert G., Govorkova, Elena A.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2005
Assuntos:
Antiviral Agents
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1251536/
https://ncbi.nlm.nih.gov/pubmed/16189083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.10.4075-4084.2005
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