Multivalent 4-1BB binding aptamers costimulate CD8(+) T cells and inhibit tumor growth in mice

4-1BB is a major costimulatory receptor that promotes the survival and expansion of activated T cells. Administration of agonistic anti–4-1BB Abs has been previously shown to enhance tumor immunity in mice. Abs are cell-based products posing significant cost, manufacturing, and regulatory challenges...

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Bibliografiske detaljer
Main Authors: McNamara, James O., Kolonias, Despina, Pastor, Fernando, Mittler, Robert S., Chen, Lieping, Giangrande, Paloma H., Sullenger, Bruce, Gilboa, Eli
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2007
Fag:
Technical Advance
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2104483/
https://ncbi.nlm.nih.gov/pubmed/18060045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI33365
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