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Targeting 4-1BB Costimulation to Disseminated Tumor Lesions With Bi-specific Oligonucleotide Aptamers

The paucity of costimulation at the tumor site compromises the ability of tumor-specific T cells to eliminate the tumor. Here, we show that bi-specific oligonucleotide aptamer conjugates can deliver costimulatory ligands to tumor cells in situ and enhance antitumor immunity. In poorly immunogenic su...

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書誌詳細
主要な著者: Pastor, Fernando, Kolonias, Despina, McNamara II, James O, Gilboa, Eli
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group 2011
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3188744/
https://ncbi.nlm.nih.gov/pubmed/21829171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2011.145
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