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Multivalent 4-1BB binding aptamers costimulate CD8(+) T cells and inhibit tumor growth in mice
4-1BB is a major costimulatory receptor that promotes the survival and expansion of activated T cells. Administration of agonistic anti–4-1BB Abs has been previously shown to enhance tumor immunity in mice. Abs are cell-based products posing significant cost, manufacturing, and regulatory challenges...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2104483/ https://ncbi.nlm.nih.gov/pubmed/18060045 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI33365 |
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