MRP1-CD28 bi-specific oligonucleotide aptamers: target costimulation to drug-resistant melanoma cancer stem cells

In this work we show a clinically feasible strategy to convert in situ the own tumor into an endogenous vaccine by coating the melanoma cancerous cells with CD28 costimulatory ligands. This therapeutic approach is aimed at targeting T-cell costimulation to chemotherapy-resistant tumors which are ref...

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Dades bibliogràfiques
Publicat a:Oncotarget
Autors principals: Soldevilla, Mario Martínez, Villanueva, Helena, Casares, Noelia, Lasarte, Juan Jose, Bendandi, Maurizio, Inoges, Susana, de Cerio, Ascensión López-Díaz, Pastor, Fernando
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2016
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5029619/
https://ncbi.nlm.nih.gov/pubmed/26992239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8095
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