MRP1-CD28 bi-specific oligonucleotide aptamers: target costimulation to drug-resistant melanoma cancer stem cells

In this work we show a clinically feasible strategy to convert in situ the own tumor into an endogenous vaccine by coating the melanoma cancerous cells with CD28 costimulatory ligands. This therapeutic approach is aimed at targeting T-cell costimulation to chemotherapy-resistant tumors which are ref...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Soldevilla, Mario Martínez, Villanueva, Helena, Casares, Noelia, Lasarte, Juan Jose, Bendandi, Maurizio, Inoges, Susana, de Cerio, Ascensión López-Díaz, Pastor, Fernando
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5029619/
https://ncbi.nlm.nih.gov/pubmed/26992239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8095
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