CD28 Aptamers as Powerful Immune Response Modulators

CD28 is one of the main costimulatory receptors responsible for the proper activation of T lymphocytes. We have isolated two aptamers that bind to the CD28 receptor. As a monomer, one of them interfered with the binding of CD28 to its ligand (B7), precluding the costimulatory signal, whereas the oth...

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Bibliographische Detailangaben
Hauptverfasser: Pastor, Fernando, Soldevilla, Mario M, Villanueva, Helena, Kolonias, Despina, Inoges, Susana, de Cerio, Ascensión L, Kandzia, Romy, Klimyuk, Victor, Gleba, Yuri, Gilboa, Eli, Bendandi, Maurizio
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2013
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3696906/
https://ncbi.nlm.nih.gov/pubmed/23756353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2013.26
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