Reactivation of silenced, virally transduced genes by inhibitors of histone deacetylase

Retroviral and adeno-associated viral sequences can dramatically silence transgene expression in mice. We now report that this repression also occurs in stably infected HeLa cells when the cells are grown without selection. Expression of a transduced lacZ gene (rAAV/CMVlacZ) is silenced in greater t...

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Bibliographic Details
Main Authors: Chen, Wen Yong, Bailey, Evans C., McCune, Steven L., Dong, Jian-Yun, Townes, Tim M.
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences of the USA 1997
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC20860/
https://ncbi.nlm.nih.gov/pubmed/9159154
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